Cell cycle control of polyomavirus-induced transformation
نویسندگان
چکیده
منابع مشابه
Mechanisms of cell transformation induced by polyomavirus.
Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic prot...
متن کاملRAS pathways to cell cycle control and cell transformation.
Ras genes are among the most frequently activated oncogenes in cancer. The corresponding protooncogenes are proteins expressed in the majority of tissues in mammals and have a signal transduction activity. Ras proteins interact with a wide spectrum of regulators and downstream effectors producing different cellular responses, including proliferation, differentiation or apoptosis. This review de...
متن کاملCell cycle control of BRCA2.
Identifying the conditions and kinetics of the induction of BRCA2 gene expression may implicate roles for the function of the tumor suppressor gene. In this study, expression of BRCA2 mRNA is shown to be regulated by the cell cycle and associated with proliferation in normal and tumor-derived breast epithelial cells. Cells arrested in G(0) or early G1 contained low levels of BRCA2 mRNA. After r...
متن کاملCell Cycle: Principles of Control
tion at the end of each case. For students desiring a more in-depth review, the analysis section of each case provides a great and more detailed overview. An extra index organized by disorder name in the back also allows the reader to focus on particular aspects of internal medicine. Details such as this make it obvious that the authors have tried to cater to the varying needs of their readers,...
متن کاملPolycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication
The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity to cancer. PcGs silence the expression of the tumour suppressor locus Ink4a/Arf, whose products positively regulate pRb and p53 functions. Enhanced PcG activity is a frequent feature of human tumours, and PcG inhibition has been proposed as a strategy for cancer treatment. However, the rec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 1993
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.67.4.1996-2005.1993